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Atropine Eye Drops

Atropine Eye Drops Winnipeg

Are you looking for compounded atropine eye drops in Winnipeg? 

Our compounding pharmacy makes low-dose atropine eye drops in 0.01%, 0.02% and 0.05% concentrations.  These low-dose concentrations are used in the treatment of myopia (nearsightedness) in children.

Atropine sulfate ophthalmic solution produced by drug manufacturing companies is only available in an atropine 1% solution.  Only the 1% version of this medication is available commercially.

We compound the lower percentage eye drops for those patients with vision problems such as myopia.  For the treatment of myopic vision a lower strength atropine product is required.

Studies have shown that atropine drops are well tolerated and effective in slowing the progression of low and moderate myopia in children.

In fact, a 2019 study by Jason C Yam et al. published in the journal Ophthalmology and titled “Low-concentration atropine for myopia progression (LAMP) study: a randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025%, and 0.01% atropine eye drops in myopia control” found and concluded the following:

“The 0.05%, 0.025%, and 0.01% atropine eye drops reduced myopia progression along a concentration-dependent response.

All concentrations were well tolerated without an adverse effect on vision-related quality of life.

Of the 3 concentrations used, 0.05% atropine was most effective in controlling SE progression and AL elongation over a period of 1 year.”

To see the study abstract visit the Science Direct website here.

To learn more call the pharmacy at (204) 233-3469 to speak to our compounding department, email us at tache@mts.net or visit our contact us page for more contact information.

Do you have a prescription for a low-dose atropine ophthalmic drops?  Feel free to use our online prescription order form to submit your prescription to us.

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What is atropine sulfate?

Atropine sulfate is an anticholinergic drug.  More specifically, it is an antimuscarinic agent.  This means it blocks the effects of acetylcholine at muscarinic nerve endings.

Muscarinic receptors are found in the parasympathetic and sympathetic nervous systems as well as the central nervous system.

Within the parasympathetic nervous system the muscarinic receptors are found in the cardiac conduction system, the exocrine gland and in smooth muscles.  Muscarinic receptors are found to a lesser degree in the sympathetic nervous system where they are found in sweat glands.

Atropine effects the smooth muscles of the eye. 

It is this effect of the medicine which makes it useful in treating certain vision conditions.  Different concentrations (i.e. 1% vs. 0.1%) will produce different effects in the eye.

What is atropine sulfate 1% solution used for?

Atropine blocks the effects of acetylcholine on the smooth muscles of the eyes.  By blocking the effects of acetylcholine in the eye, atropine causes the pupils to dilate (become larger/more open).  A drug that dilates the pupil is known as a mydriatic.

Atropine also paralyzes the ciliary muscles of the eye.  This means that the lens of the eye can no longer be adjusted by the ciliary muscles.  Drugs that have this action on the eye are known as cycloplegic.

Since atropine causes the pupils to dilate, and it paralyzes the ciliary muscles, it is used in eye examinations and to treat certain conditions of the eye.

The eye conditions that atropine sulfate 1% ophthalmic solution is used to treat include iritis and uveitis.   Iritis is inflammation of the iris. Uveitis is an inflammation of the middle layer of the eye known as the uvea.

Atopine drops can also be used off-label to decrease excessive drooling.  Atropine eye drops for drooling are applied sublingually (under the tongue).

Veterinarians also use atropine eye drops for dogs and cats.  They will use these drops to reduce eye pain in dogs and cats.

What are atropine eye drops 0.01%, 0.02% and 0.05% used for?

Atropine eye drops in 0.01%, 0.02% and 0.05% concentrations are known as low-dose atropine.

Low-dose atropine ophthalmic drops are used to slow the progression of myopia.

Myopia is also known as nearsightedness.  This is a common eye condition in which you are able to see objects close to you clearly, however objects which are further away appear blurry.

If myopia progresses to high myopia the risk of developing serious eye diseases increases.  These serious eye diseases include choroidal neo­vascularization, glaucoma and retinal detachment.

In recent years, low-dose atropine ophthalmic drops have become recognized as an effective treatment option for slowing the progression of myopia.

Studies show that atropine 0.01% has minimal side effects when compared with atropine at 0.1% and 0.5% concentrations.  While producing less side effects, the 0.01% concentration still retains comparable efficacy in controlling myopia progression.

How do I use low-dose atropine eye drops?

The usual dose of atropine eye drops is one drop in each eye daily.  The drops can be applied at any time of the day preferred by the patient.  The drops should be administered at the same time each day.

Low dose atropine drops should be used for a minimum of 6 months.

How long does the therapeutic effect of atropine eye drops last?

The therapeutic effects of atropine in the eye begin about 40 minutes after application of the drops.  The peak effect is seen approximately 2 hours after application.

In a normal eye, the effects of atropine can last up to 2 weeks.  These numbers were reported for the 1% eye drops.

There is less data regarding the low-dose and very low-dose atropine drops.

This study does report some findings.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208716/

The authors of the study found that the 0.01% solution did produce noticeable effects on pupil size and accommodation for a 24 hour period.

What are some atropine eye drops side effects?

Low-dose atropine ophthalmic drops are usually well tolerated with minimal side effects.

Within the eye, low-dose atropine has only a small effect on accommodation (ability of the ciliary muscles to adjust the shape of the lens), near vision and the size of the pupil.

Systemic side effects can occur but are quite rare due to the low dosage of the eye drops.

Potential systemic side effects include increased heart rate, dry mouth, urinary retention, constipation, altered mental status and flushing skin.

The commercially available 1% solution is more likely to cause systemic side effects when applied to the eye.  One side effect of concern is atropine drops effect on blood pressure. If there is significant systemic absorption atropine eye drops can elevate blood pressure.

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More Information on Low-Dose Atropine Ophthalmic Drops

https://www.aao.org/eyenet/article/how-to-use-low-dose-atropine-to-slow-myopic-progre

https://www.nature.com/articles/s41433-018-0139-7

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