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Diazepam Suppository

Diazepam Suppository in Winnipeg

Diazepam suppository for the treatment of pelvic pain is available in Winnipeg.

Do you suffer from pelvic pain?  Are you looking for a compounding pharmacy that makes diazepam vaginal suppositories?

The compounding lab at Tache Pharmacy makes diazepam mini suppositories.

To find out more about our diazepam vaginal mini suppositories please call us at (204) 233-3469 to speak to one of our compounding lab staff members.

Diazepam Vaginal Suppository

What is diazepam?

Diazepam is a medication that belongs to the group of drugs known as benzodiazepines.

Benzodiazepines work by enhancing the effects of the neurotransmitter GABA.  GABA or Gamma-aminobutyric acid is a neurotransmitter that has anti-convulsant, sedating, sleep-inducing, anti-anxiety and muscle-relaxant properties.

GABA is known as an inhibitory neurotransmitter.  This means it is “relaxing” rather than excitatory.  It reduces neuronal (nerve) excitability.  In fact, GABA is the main inhibitory neurotransmitter in the body.  GABA’s function is to “slow down” the nervous system.

At certain receptors on neurons (nerve cells), known as GABA-A receptors, GABA binds and allows chloride ions to enter the cell.  This movement of chloride ions into the cell makes it less responsive to excitatory neurotransmitters.

Benzodiazepines also have their own special receptors on the GABA-A receptor.  When a benzodiazepine binds to these receptors it makes the nerve cell more responsive to the actions of GABA.  The combination of a benzodiazepine and GABA at the GABA-A receptor leads to even more chloride ions entering the cell.  This means the cells becomes even less responsive to excitatory neurotransmitters.

What is diazepam suppository used for?

Diazepam suppository is used to treat women with pelvic pain.  More specifically, diazepam vaginal suppositories are used to treat women with high-tone pelvic floor dysfunction.

The diazepam, a benzodiazepine, is utilized for its muscle-relaxing effects.  Since diazepam elevates the effects of GABA in reducing the excitatory effects of other neurotransmitters it is able to produce a reduction in the muscle tone in the pelvic region.

The delivery of the drug through a vaginal suppository helps to deliver the medication to the area it is most needed to produce its effects.

What is high-tone pelvic floor dysfunction?

High-tone pelvic floor dysfunction may go by several different names including:

  • hypertonic pelvic floor dysfunction
  • non-relaxing pelvic floor dysfunction
  • pelvic muscle spasms

When talking about high-tone pelvic floor dysfunction, muscle tone is not referring to having big muscles or toned muscles that you can see.  Muscle tone, in this case, refers to the state of contraction of the muscle.

When a muscle is very contracted and rigid it is said to be hypertonic or have high tone.  When a muscle is very relaxed and not contracted at all it is said to be hypotonic or low tone.

So as you can see, high-tone pelvic floor dysfunction is a condition in which the muscles of the pelvic floor are in a constant state of being in a contracted state.  This contracted state leads to pain and discomfort.  It can even result in sexual pain and discomfort.

How effective are diazepam vaginal suppositories in treating hypertonic pelvic floor dysfunction?

In a 2010 study by Matthew Rogalski et al, titled “Retrospective chart review of vaginal diazepam suppository use in high-tone pelvic floor dysfunction” it was found that:

“Vaginal diazepam suppositories gave a clinically significant improvement in the treatment of HTPFD compared with the usual treatment regimen alone.”

It is important to note that this study is saying that diazepam vaginal suppositories significantly help when added to other treatments.  The other treatments people received were pelvic physical therapy and intramuscular trigger point injections for bladder pain, sexual pain, and levator hypertonus.

What are the diazepam suppository side effects?

The potential diazepam suppository side effects include:

  • drowsiness
  • local vaginal irritation
  • dizziness
  • headache
  • pain
  • stomach pain
  • nervousness
  • flushing
  • diarrhea
  • unsteadiness
  • abnormal ‘high’ mood
  • lack of coordination
  • runny nose
  • problems falling asleep or staying asleep

Please let one of our pharmacists, or your prescriber, know if you experience any of these or any other side effects.

How do I obtain diazepam mini suppositories from Tache Pharmacy?

A prescription is required to obtain diazepam suppositories.  You will need to discuss your condition with your prescriber.

If you already have a prescription for these suppositories please feel free to submit it online using our online prescription order form.

To learn more about using diazepam vaginal suppositories for the treatment of high-tone pelvic floor dysfunction visit

For a physiotherapist in Winnipeg who specializes in the pelvic floor please visit Jamie Angus Physiotherapy.