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Hydroquinone Cream

Hydroquinone Cream in Winnipeg

Are you looking to buy hydroquinone cream in Winnipeg?  Do you need a combination hydroquinone cream?

Our compounding pharmacy regularly compounds hydroquinone (HQ) cream and combination hydroquinone creams.

How Effective Are HQ Creams?

Are you wondering how effective HQ cream and/or HQ combination creams are in treating melasma and other hyperpigmentation disorders (dark spots)?

A 2007 study by Tania Ferreira Cestari et al. published in the Journal of Cosmetic Dermatology titled “A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma” found and concluded the following:

Improvement of more than 75% was achieved by 73% of Triple Combination (TC) cream patients and 49% of HQ cream patients (P = 0.007).

The incidence of adverse events (erythema, burning sensation, and desquamation) was similar in both groups. No patient dropped out of the study because of drug‐related adverse events.

TC cream was more effective than the HQ cream for the treatment of moderate to severe facial melasma. Both products had similar safety profiles.”

The triple combination cream is a mixture of fluocinolone acetonide 0.01%, hydroquinone (HQ) 4% and tretinoin 0.05%.  We also make this combination cream.

As you can see, these creams are very effective.

Call us today at (204) 233-3469 or email us at for more information about our hydroquinone cream or visit our contact us page for alternative contact methods.

Do you have a prescription for hydroquinone topical?  Feel free to use our online prescription order form to submit your prescription to us.

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What is hydroquinone?

The chemical name for hydroquinone is 1,4-dihydroxybenzene.

What is melanin?

Melanin is a natural pigment found in skin.  Melanin is what makes skin, hair and eyes darker.

How does hydroquinone work?

When applied topically, hydroquinone causes a reversible depigmentation of the skin.

Hydroquinone produces this depigmentation via two processes:

  1. By blocking the enzyme tyrosinase from forming 3,4-dihydroxyphenylalanine from tyrosine.
  2. Reducing various melanocyte metabolic processes.

By effecting these two steps in the process, hydroquinone stops the melanization (formation of melanin).

Studies have found that hydroquinone affects the melanocyte system. 

It causes reduced production of melanosomes, a significant change in the internal structure of melanosomes, an increase in the breakdown of melanosomes and the destruction of organelles found in the melanocytes.

These effects lead to depigmentation.

What is hydroquinone cream used for?

Hydroquinone is used to treat dark spots on the skin or for skin lightening.  Basically people use hydroquinone for hyperpigmentation.

Hydroquinone is used in conditions of skin hyperpigmentation including:

  • Chloasma
  • Melasma
  • Freckles
  • Senile lentigines

Hydroquinone treatment may also be used for scars and thermal burns.

A 2012 study by Xue-wen Qiu et al. published in the Chinese Journal of Aesthetic Medicine under the title “Effect of hydroquinone cream combined with collagen dressing on postburn hyperpigmentation” concluded the following:

“Hydroquinone cream combined with collagen dressing has very significant therapeutic efficacy on postburn hyperpigmentation with superior safety.”

Hydroquinone has been found to be one of the best inhibitors of melanogenesis.  It is used extensively for the treatment of melanosis and other hyperpigmentary disorders such as melasma.

How long until I start to see results?

Dark spot lightening does take some time with hydroquinone treatment.  On average it takes about 4 weeks to start seeing results. It can take up to 3 months or more to see the full benefits.

Are there any side effects with hydroquinone cream?

Potential side effects include:

  • Skin sensitivity reactions
  • Skin redness
  • Drying and flaking of skin
  • Hypersensitivity or allergic reactions

It is a good idea to test for skin sensitivity.  Test just a small amount on your skin. Make sure it is a healthy area of skin with no cuts or scrapes.  Observe the application site for 24 hours. Some redness does not indicate skin sensitivity but itching and excessive redness and inflammation does.  Discuss this with your prescriber if it does occur.

Mild redness and slight burning does not necessarily mean that treatment needs to be stopped.  Discuss this with your prescriber or pharmacist.

What other ingredients can hydroquinone be combined with?

In order to improve the effectiveness of hydroquinone cream it can be combined with other ingredients such as:

  • Tretinoin
  • Glycolic acid
  • Hydrocortisone
  • Lactic acid
  • Ascorbic acid
  • Fluocinolone
  • Kojic acid

Are there any other precautions?

Be sure to use sunscreen and avoid exposure to lots of sunlight in order to prevent repigmentation of the treated areas.

The effects of hydroquinone in pregnancy are not well studied.  Topical hydroquinone should be used by a woman who is pregnant only if absolutely required.

Compounded hydroquinone cream should be refrigerated.

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